Self-Assembled Generation of Multi-zonal Liver Organoids from Human Pluripotent Stem Cells

Abstract excerpt

Distinct hepatocyte subpopulations are spatially segregated along the portal-central axis and critical to understanding metabolic homeostasis and liver injury. While several bioactive molecules have been described to play a role in directing zonal fates, including ascorbate and bilirubin, in vitro replication of zonal liver architecture has not been achieved to date. In order to evaluate hepatic zonal polarity, w...

Topics

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• 3D Printing in Biomedical Research
• Liver physiology and pathology
• MicroRNA in disease regulation
• Mitochondrial Function and Pathology
• Organ Transplantation Techniques and Outcomes
• Pancreatic function and diabetes
• Pluripotent Stem Cells Research
• Single-cell and spatial transcriptomics

Identifiers and source

Literature Corpus work

d8263e4a-972c-5692-8295-f3bc9e7401d7

DOI

10.1101/2024.08.30.610426