Article

Expandable, Functional Hepatocytes Derived from Primary Cells Enable Liver Therapeutics

2024-12-28

Abstract excerpt

Liver disease affects millions annually in the United States, with orthotopic transplantation as the only curative option for many patients. However, the scarcity of donor organs highlights a need for alternative cell-based therapies. Hepatocyte-based approaches are promising due to the cells’ inherent synthetic, metabolic, and detoxifying functions, but they face critical barriers, including the lack of a scalabl...

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Literature Corpus work: 3849a6ae-d293-51e4-97ff-4455732f44f8
DOI: 10.1101/2024.12.28.630269

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