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Article

Multi‐omics analysis unveils the role of inflammatory cancer‐associated fibroblasts in chordoma progression

29 Nov 2024

Abstract excerpt

Cancer-associated fibroblasts (CAFs) constitute the primary cellular component of the stroma in chordomas, characterized by an abundance of mucinous stromal elements, potentially facilitating their initiation and progression; however, this inference has yet to be fully confirmed. In this study, single-cell RNA sequencing (scRNA-seq), spatial transcriptomics (ST), bulk RNA-seq, multiplexed quantitative...

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PMID: 39611243
DOI: 10.1002/path.6369

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