Article

DNA methylation, combined with RNA sequencing, provide novel insight into molecular classification of chordomas and their microenvironment

2023-05-06

Abstract excerpt

<h4>ABSTRACT</h4> Chordomas are rare tumors of notochord remnants, occurring mainly in the sacrum and skull base. In spite of slow growth, they are highly invasive what makes the treatment challenging. Because of low incidence the molecular background of chordomas is poorly recognized. Our study aims to determine role of DNA methylation abnormalities in skull base chordomas including its role in deregulation of g...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 31f4dc14-5b43-5e9c-900c-57acc340bc4a
DOI: 10.1101/2023.05.06.539695

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

DNA methylation, combined with RNA sequencing, provide novel insight into molecular classification of chordomas and their microenvironmentDOI 10.1101/2023.05.06.539695Read

DNA methylation, combined with RNA sequencing, provide novel insight into molecular classification of chordomas and their microenvironmentSemantic proximity Read

Genome-wide DNA methylation profiling of recurrent and non-recurrent chordomasSemantic proximity Read

Methylation-based reclassification and risk stratification of skull-base chordomasSemantic proximity Read

Chordoma Characterization of Significant Changes of the DNA Methylation PatternSemantic proximity Read

Epigenetic deregulations in chordomaSemantic proximity Read

DNA methylation-based prognostic subtypes of chordoma tumors in tissue and plasmaSemantic proximity Read

Unraveling molecular advancements in chordoma tumorigenesis and treatment response: a review of scientific discoveries and clinical implicationsSemantic proximity Read

Chordoma: Genetics and Contemporary Management.Semantic proximity Read

Gene Expression Profiling Identifies Two Chordoma Subtypes Associated with Distinct Molecular Mechanisms and Clinical OutcomesSemantic proximity Read

Single-Cell Transcriptome Profiling Reveals Intratumoral Heterogeneity in Human ChordomasSemantic proximity Read

From Histology to Multi-Omics: Review of Chordoma Classification and Its Clinical ImplicationsSemantic proximity Read

Dysregulated Epigenetics of Chordoma: Prognostic Markers and Therapeutic TargetsSemantic proximity Read