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DNA methylation-based prognostic subtypes of chordoma tumors in tissue and plasma

30 Sept 2021

Abstract excerpt

BACKGROUND: Chordomas are rare malignant bone cancers of the skull-base and spine. Patient survival is variable and not reliably predicted using clinical factors or molecular features. This study identifies prognostic epigenetic chordoma subtypes that are detected noninvasively using plasma methylomes. METHODS: Methylation profiles of 68 chordoma surgical samples were obtained between 1996 and 2018 across three...

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PMID: 34614192
DOI: 10.1093/neuonc/noab235

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