Article

Spatial transcriptomic analysis of muscle biopsy from treatment-naive juvenile dermatomyositis patients reveals mitochondrial abnormalities despite disease-related interferon driven signature

2025-06-06

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objectives</h4> This study aimed to investigate the spatial transcriptomic landscape of muscle tissue from treatment-naïve juvenile dermatomyositis (JDM) patients in comparison to healthy paediatric muscle tissue. <h4>Methods</h4> Muscle biopsies from three JDM patients and three age-matched controls were analysed using the Nanostring GeoMx® Digital Spatial Profiler. Regions of interest we...

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Literature Corpus work: 4b5e0d9d-84cf-5c50-9f4c-62f60796de2a
DOI: 10.1101/2025.06.03.657601

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