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Article

Sequencing of the human IG light chain loci from a hydatidiform mole BAC library reveals locus-specific signatures of genetic diversity.

Genes and immunity - 1 Jan 2015

Watson Corey T, Steinberg Karyn Meltz, Graves Tina A, Warren Rene L, Malig Maika, Schein Jacqueline, Wilson Richard K, Holt Robert A, Eichler Evan E, Breden Felix

Abstract excerpt

Germline variation at immunoglobulin (IG) loci is critical for pathogen-mediated immunity, but establishing complete haplotype sequences in these regions has been problematic because of complex sequence architecture and diploid source DNA. We sequenced BAC clones from the effectively haploid human hydatidiform mole cell line, CHM1htert, across the light chain IG loci, kappa (IGK) and lambda (IGL), creating single...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Source

Open in PubMed Open full text

Identifiers

PMID: 25338678
DOI: 10.1038/gene.2014.56
PMCID: PMC4304971

Genes

IGK
IGL
IGH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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