Article

Decoil: Reconstructing extrachromosomal DNA structural heterogeneity from long-read sequencing data

2023-11-17

Abstract excerpt

Circular extrachromosomal DNA (ecDNA) is a form of oncogene amplification found across cancer types and associated with poor outcome in patients. EcDNA can be structurally complex and contain rearranged DNA sequences derived from multiple chromosome locations. As the structure of ecDNA can impact oncogene regulation and may indicate mechanisms of its formation, disentangling it at high resolution from sequencing d...

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Literature Corpus work: 67233fb3-59a2-5405-8e5e-0090abfbb490
DOI: 10.1101/2023.11.15.567169

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