Article

Envelope Simulation: A New Adaptive Method for Dose Optimization

2020-03-09

Abstract excerpt

We present a flexible and general adaptive experimental design for dose finding clinical trials. This method can be applied in sterotypical settings such as determining a maximum tolerated dose, when the dose response relationship is complex, or when the response is an arbitrary quantitative measure. Our design generalizes dose finding methods such as the continual reassessment method (CRM), modified CRM, and esti...

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Literature Corpus work: 31c91477-4453-5d13-979a-5955d0d1b658
DOI: 10.1101/2020.03.09.983411

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