Article

CFO: Calibration-Free Odds Bayesian Designs for Dose Finding in Clinical Trials

2024-07-27

Abstract excerpt

The calibration-free odds type (CFO-type) of designs, as data-driven decision-making Bayesian approaches, leverage historical cumulative data across various dose levels, primarily aiming at identifying the maximum tolerated dose (MTD). Inheriting the ideas from game theory or “tug-of-war”, CFO mimics the games of force: one pushes the dose down while the other pushes it up. Extensive simulations validate that CFO-...

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Literature Corpus work: 53e86f2b-c20c-5cc6-ac54-c2b964a89590
DOI: 10.1101/2024.07.26.24311051

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