Article

Adaptive designs for complex dose finding studies

2018-01-01

Abstract excerpt

The goal of an early phase clinical trial is to find the regimen (dose, combination, schedule, etc.) satisfying particular toxicity or (and) efficacy characteristics. Designs for trials studying doses of a single cytotoxic drug are based on the fundamental assumption ~the more the better~, that is, the toxicity and efficacy increase with the dose. This monotonicity assumption can be violated for novel therapies an...

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Literature Corpus work: 8626e113-8540-5459-9ffa-be4f242a50c7
DOI: 10.17635/lancaster/thesis/364

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