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Article

Radiation therapy with phenotypic medicine: towards N-of-1 personalization.

British journal of cancer - 1 Jul 2024

Chong Li Ming, Wang Peter, Lee V Vien, Vijayakumar Smrithi, Tan Hong Qi, Wang Fu Qiang, Yeoh Teri Danielle You Ying, Truong Anh T L, Tan Lester Wen Jeit, Tan Shi Bei, Senthil Kumar Kirthika, Hau Eric, Vellayappan Balamurugan A, Blasiak Agata, Ho Dean

Abstract excerpt

In current clinical practice, radiotherapy (RT) is prescribed as a pre-determined total dose divided over daily doses (fractions) given over several weeks. The treatment response is typically assessed months after the end of RT. However, the conventional one-dose-fits-all strategy may not achieve the desired outcome, owing to patient and tumor heterogeneity. Therefore, a treatment strategy that allows for RT dose...

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Identifiers

PMID: 38514762
DOI: 10.1038/s41416-024-02653-3
PMCID: PMC11231338

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