Article

The Generalized 3+3 (G3+3) Design for Phase I Dose-Finding Trials

2024-08-19

Abstract excerpt

PURPOSE We propose and demonstrate the feasibility and desirability of a novel model-free dose-finding design for phase I clinical trials. METHODS The Generalized 3+3 (G3+3) design uses a set of simple rules summarized as follows: For 3 or 6 patients at a dose, apply the 3+3 design for making dosing decisions. For other numbers, if the observed toxicity rate (OTR) is less than 0.2, escalate to the next higher dose...

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Literature Corpus work: e17cb72a-ca56-55af-9364-414149b5875b
DOI: 10.1101/2024.08.18.24312178

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