Article

Deriving Optimal Treatment Timing for Adaptive Therapy: Matching the Model to the Tumor Dynamics

2025-04-03

Abstract excerpt

Adaptive therapy (AT) protocols have been introduced to combat drug-resistance in cancer, and are characterized by breaks in maximum tolerated dose treatment (the current standard of care in most clinical settings). These breaks are scheduled to maintain tolerably high levels of tumor burden, employing competitive suppression of treatment-resistant sub-populations by treatment-sensitive sub-populations. AT has bee...

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Literature Corpus work: 14615038-27f5-5d88-9f8d-dc931791c404
DOI: 10.1101/2025.04.01.25325056

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