Article

Dissecting serum polyclonal antibody escape to SARS-CoV-2 variants by deep mutational learning

2025-05-02

Abstract excerpt

The rapid emergence of SARS-CoV-2 variants harboring multiple receptor-binding domain (RBD) mutations continues to challenge the efficacy of vaccines and antibody therapeutics. While deep mutational scanning (DMS) has been instrumental in mapping single-mutation effects on antibody binding and immune escape, it remains limited in its ability to assess combinatorial mutational landscapes. Here, we extend deep mutat...

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Literature Corpus work: 31b76090-52e7-5d18-87d4-4b47b058bed0
DOI: 10.1101/2025.05.01.651552

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