Dissecting serum polyclonal antibody escape to SARS-CoV-2 variants by deep mutational learning.

Abstract excerpt

Deep mutational scanning (DMS) has been extensively used to investigate how single-position mutations in the receptor-binding domain (RBD) affect binding of ACE2 and neutralizing antibodies, thus revealing mutations that drive immune escape. However, these mutations represent only a small fraction of the combinatorial mutational space. Here, we present deep mutational learning (DML), a method integrating...

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