Article
Deep mutational learning predicts ACE2 binding and antibody escape to combinatorial mutations in the SARS-CoV-2 receptor-binding domain.
Cell - 13 Oct 2022
Taft Joseph M, Weber Cédric R, Gao Beichen, Ehling Roy A, Han Jiami, Frei Lester, Metcalfe Sean W, Overath Max D, Yermanos Alexander, Kelton William, Reddy Sai T
Abstract excerpt
The continual evolution of SARS-CoV-2 and the emergence of variants that show resistance to vaccines and neutralizing antibodies threaten to prolong the COVID-19 pandemic. Selection and emergence of SARS-CoV-2 variants are driven in part by mutations within the viral spike protein and in particular the ACE2 receptor-binding domain (RBD), a primary target site for neutralizing antibodies. Here, we develop deep...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.