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Article

Evaluating SARS-CoV-2 antibody resilience via prediction and design of escape viral variants.

Cell systems - 16 Sept 2026

Huot Marian, Rosenbaum Pierre, Planchais Cyril, Mouquet Hugo, Monasson Rémi, Cocco Simona

Abstract excerpt

The evolutionary trajectory of SARS-CoV-2 is shaped by competing pressures for angiotensin-converting enzyme 2 (ACE2) binding, viability, and escape from neutralizing antibodies targeting its receptor-binding domain (RBD). Here, we present EscapeMap, a modular framework that enables the prediction and design of variants escaping antibodies. EscapeMap integrates deep mutational scanning data for ACE2 and 31...

Read the complete abstract on PubMed

Topics

SARS-CoV-2
Humans
Antibodies, Neutralizing
Angiotensin-Converting Enzyme 2
Mutation
Antibodies, Viral

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

COVID-19

Antibodies, Monoclonal

Spike Glycoprotein, Coronavirus

Protein Binding

Source

Identifiers

PMID: 42468530
DOI: 10.1016/j.cels.2026.101673

Genes

ACE2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 21 Oct 2026.

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