Article

Evaluating SARS-CoV-2 Antibody Resilience via Prediction and Design of Escape Viral Variants

2025-05-13

Abstract excerpt

<h4>SUMMARY</h4> The evolutionary trajectory of SARS-CoV-2 is shaped by competing pressures for ACE2 binding, viability, and escape from neutralizing antibodies targeting its receptor-binding domain (RBD). Here, we present EscapeMap, a modular framework that enables prediction and design of variants escaping antibodies. EscapeMap integrates deep mutational scanning data for ACE2 and 31 monoclonal antibodies with...

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Literature Corpus work: 483f4487-d512-5fdf-8290-a2ba75393aa7
DOI: 10.1101/2025.05.12.653592

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