Back to search

Article

BBB dysfunction drives neurotoxic myeloid cells in glioblastoma and Alzheimer’s disease

2023-11-21

Abstract excerpt

<h4>Background: </h4> The blood-brain barrier (BBB) defines the physiological function of the brain and is disrupted in multiple neuropathological diseases. Although vascular abnormalities and BBB leakage characterize glioma progression and occurs in the early stages of Alzheimer's disease (AD), their correlation with the neurodegeneration observed in the brain parenchyma is unclear. <h4>Methods: </h4> Using RNAs...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
31b063ae-6b8e-5e74-8106-60b60de32bd4
DOI
10.21203/rs.3.rs-3610020/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
BBB dysfunction drives neurotoxic myeloid cells in glioblastoma and Alzheimer’s diseaseDOI 10.21203/rs.3.rs-3610020/v1
BBB Dysfunction Defines the Aging Myeloid Landscape Favoring Immune Evasion for Glioma and Alzheimer's DiseaseSemantic proximity
Targeting Neuroinflammation in Brain Cancer: Uncovering Mechanisms, Pharmacological Targets, and Neuropharmaceutical DevelopmentsSemantic proximity
Transcriptomic Analysis Identified two Subtypes of Brain Tumor Characterized by Distinct Immune Infiltration and PrognosisSemantic proximity
Myeloproliferative blood cancers as a human neuroinflammation model for development of Alzheimer's disease: evidences and perspectives.Semantic proximity
Circulating senescent myeloid cells drive blood brain barrier breakdown and neurodegenerationSemantic proximity
Inflammatory reprogramming of human brain endothelial cells compromises blood–brain barrier integrity in Alzheimer’s diseaseSemantic proximity
Spatial patterning and immunosuppression of glioblastoma immune contexture in hypoxic nichesSemantic proximity
Glioblastoma and its treatment are associated with extensive accelerated brain agingSemantic proximity
Signatures for Viral Infection and Inflammation in the Proximal Olfactory System in Familial Alzheimer’s DiseaseSemantic proximity
Brain endothelial cells are exquisite sensors of age-related circulatory cuesSemantic proximity
Dynamics of glioma-associated microglia and macrophages reveals their divergent roles in the immune response of brainSemantic proximity
Interrogation of the Microenvironmental Landscape in Brain Tumors Reveals Disease-Specific Alterations of Immune CellsSemantic proximity
Select a neighboring publication to make it the new centre.