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Article

Mutational signatures in blood-brain barrier: mechanisms, computational insights, and clinical applications in precision oncology.

Tissue barriers - 1 Jan 2026

Krishna Hare, Singh Vinod Kumar, Awasthi Seema, Kumar Ajay

Abstract excerpt

The blood - brain barrier (BBB) plays a central role in maintaining central nervous system (CNS) homeostasis, and its disruption is a defining feature of malignant brain tumors such as glioblastoma. Emerging evidence indicates that BBB dysfunction not only alters the tumor microenvironment but also shapes the mutational processes that drive genomic instability in CNS malignancies. This review synthesizes current...

Read the complete abstract on PubMed

Topics

Humans
Blood-Brain Barrier
Mutation
Precision Medicine
Brain Neoplasms
Animals

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Identifiers

PMID: 42063272
DOI: 10.1080/21688370.2026.2664236
PMCID: PMC13540230

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 26 Oct 2026.

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