Article

Coupled fibromodulin and SOX2 signaling as a critical regulator of distant metastasis initiation in melanoma

2022-01-17

Abstract excerpt

<title>Abstract</title> <p>We aimed to study mechanisms controlling the transition from dormant to clinically relevant brain metastases, a critical process responsible for the majority of melanoma deaths. To this end, we developed <italic>in vivo</italic> models that accurately mimic this switch and identified novel molecular events that can be ascribed to their distinct phenotypes, latent or highly metastatic. I...

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Identifiers and source

Literature Corpus work: 31a9373e-d757-502f-bc33-3ffe53c25a82
DOI: 10.21203/rs.3.rs-1244262/v1

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