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Article

Tau normal function influences Niemann-Pick type C disease pathogenesis in mice and modulates autophagy in NPC1-deficient cells.

Autophagy - 1 May 2009

Pacheco Chris D, Elrick Mathew J, Lieberman Andrew P

Abstract excerpt

The tauopathies are a diverse class of devastating neurodegenerative disorders, characterized by the hyperphosphorylation and aggregation of the microtubule binding protein tau. Niemann-Pick type C disease (NPC) is a tauopathy that affects children,and is caused by mutations in intracellular lipi...

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Identifiers

PMID: 19332999
DOI: 10.4161/auto.5.4.8364
PMCID: PMC2704906

Genes

NPC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19332999-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Tau normal function influences Niemann-Pick type C disease pathogenesis in mice and modulates autophagy in NPC1-deficient cells.PMID 19332999Read ↗

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