Article

CW-Tau fights proteinopathy by improving autophagy and diminishing Tau seeding activity

2025-05-29

Abstract excerpt

<title>Abstract</title> <p>CW-Tau, a novel MAPT transcript variant generated by intron 12 retention, has been identified. Compared with classical Tau isoforms, this isoform has greater microtubule-binding properties, a reduced aggregation propensity, and faster turnover. Notably, CW-Tau RNA and protein levels are decreased in Alzheimer’s disease (AD) brains. To investigate its molecular interactions, we performed...

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Literature Corpus work: 55f84b50-a0f6-58a2-b1b8-e98821359a2b
DOI: 10.21203/rs.3.rs-6725217/v1

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