Article

<i>TSC1</i> loss-of-function increases risk for tauopathy by inducing tau acetylation and preventing autophagy-mediated tau clearance

2020-11-08

Abstract excerpt

Age-associated neurodegenerative disorders demonstrating tau-laden intracellular inclusions, including Alzheimer’s disease (AD), frontotemporal lobar degeneration (FTLD) and progressive supranuclear palsy (PSP), are collectively known as tauopathies. The vast majority of human tauopathies accumulate non-mutant tau rather than mutant forms of the protein, yet cell and animal models for non-mutant tauopathies are la...

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Literature Corpus work: f0fb528f-9579-599e-8a73-0d7bdf8474d2
DOI: 10.1101/2020.11.08.371922

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