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A core network in the SARS-CoV-2 nucleocapsid NTD mediates structural integrity and selective RNA-binding.

Nature communications - 9 Dec 2024

Dhamotharan Karthikeyan, Korn Sophie M, Wacker Anna, Becker Matthias A, Günther Sebastian, Schwalbe Harald, Schlundt Andreas

Abstract excerpt

The SARS-CoV-2 nucleocapsid protein is indispensable for viral RNA genome processing. Although the N-terminal domain (NTD) is suggested to mediate specific RNA-interactions, high-resolution structures with viral RNA are still lacking. Available hybrid structures of the NTD with ssRNA and dsRNA provide valuable insights; however, the precise mechanism of complex formation remains elusive. Similarly, the molecular...

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Coronavirus Nucleocapsid Proteins
COVID-19
Magnetic Resonance Spectroscopy
Nucleocapsid
Nucleocapsid Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Protein Domains

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PMID: 39653699
DOI: 10.1038/s41467-024-55024-0
PMCID: PMC11628620

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