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Article

The Dengue Virus NS5 Protein Intrudes in the Cellular Spliceosome and Modulates Splicing

30 Aug 2016

Abstract excerpt

Dengue virus NS5 protein plays multiple functions in the cytoplasm of infected cells, enabling viral RNA replication and counteracting host antiviral responses. Here, we demonstrate a novel function of NS5 in the nucleus where it interferes with cellular splicing. Using global proteomic analysis of infected cells together with functional studies, we found that NS5 binds spliceosome complexes and modulates...

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PMID: 27575636
DOI: 10.1371/journal.ppat.1005841

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