Article
The exon junction core complex is locked onto RNA by inhibition of eIF4AIII ATPase activity.
Nature structural & molecular biology - 1 Oct 2005
Ballut Lionel, Marchadier Brice, Baguet Aurélie, Tomasetto Catherine, Séraphin Bertrand, Le Hir Hervé
Abstract excerpt
The multiprotein exon junction complex (EJC) is assembled on mRNAs as a consequence of splicing. EJC core components maintain a stable grip on mRNAs even as the overall EJC protein composition evolves while mRNAs travel to the cytoplasm. Here we show that recombinant EJC subunits MLN51, MAGOH and Y14, together with the DEAD-box protein eIF4AIII bound to ATP, are necessary and sufficient to form a highly stable...
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