Article

Enhancing HBV-specific T cell responses through a combination of epigenetic modulation and immune checkpoint inhibition

2024-09-08

Abstract excerpt

<h4>Objective</h4> Chronic hepatitis B virus (HBV) infection results in the exhaustion of HBV-specific T cells and the development of epigenetic imprints that impair immune responses and limit the effectiveness of immune checkpoint inhibitor (ICI) monotherapy, such as αPD-L1. This study aimed to determine whether the DNA methyltransferase inhibitor decitabine (DAC) can reverse these epigenetic imprints and enhanc...

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Literature Corpus work: 0e83fad4-1c96-5716-93d2-c70ac526b107
DOI: 10.1101/2024.09.06.611632

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