Natural immune escape mutations in the envelope proteins of hepatitis B virus (HBV) regulate the assembly and infectivity of human hepatitis delta virus (HDV).

Abstract excerpt

The study examined how 35 natural immune escape mutations (IEMs) of hepatitis B virus (HBV) located in the major antigenic loop (MAL) of the envelope proteins regulate the assembly and infectivity of the natural sub-viral agent of HBV, hepatitis delta virus (HDV). All IEMs were permissive for the assembly and secretion of HDV virions. Only seven IEMs resulted in considerably decreased levels of secreted HDV...

Topics

• Hepatitis Delta Virus
• Humans
• Hepatitis B virus
• Immune Evasion
• Viral Envelope Proteins
• Virus Assembly