Article

Aberrant B cell differentiation with reduced hypermutation limits humoral response maintenance and breadth in cancer patients

2026-08-22

Abstract excerpt

<title>Abstract</title> <p>Patients with solid cancers exhibit impaired humoral immunity, yet the underlying B cell–intrinsic mechanisms remain incompletely characterized. Here, we leveraged longitudinal SARS-CoV-2 vaccination as a model of defined antigen exposure to dissect B cell responses in cancer patients. Despite preserved early expansion following booster vaccination, cancer patients failed to sustain lon...

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Literature Corpus work: f104bee3-c122-5e9e-8a06-12aa21c49650
DOI: 10.21203/rs.3.rs-10469973/v1

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