Article
The origin and evolution of mutations in acute myeloid leukemia.
Cell - 20 Jul 2012
Welch John S, Ley Timothy J, Link Daniel C, Miller Christopher A, Larson David E, Koboldt Daniel C, Wartman Lukas D, Lamprecht Tamara L, Liu Fulu, Xia Jun, Kandoth Cyriac, Fulton Robert S, McLellan Michael D, Dooling David J, Wallis John W, Chen Ken, Harris Christopher C, Schmidt Heather K, Kalicki-Veizer Joelle M, Lu Charles, Zhang Qunyuan, Lin Ling, O'Laughlin Michelle D, McMichael Joshua F, Delehaunty Kim D, Fulton Lucinda A, Magrini Vincent J, McGrath Sean D, Demeter Ryan T, Vickery Tammi L, Hundal Jasreet, Cook Lisa L, Swift Gary W, Reed Jerry P, Alldredge Patricia A, Wylie Todd N, Walker Jason R, Watson Mark A, Heath Sharon E, Shannon William D, Varghese Nobish, Nagarajan Rakesh, Payton Jacqueline E, Baty Jack D, Kulkarni Shashikant, Klco Jeffery M, Tomasson Michael H, Westervelt Peter, Walter Matthew J, Graubert Timothy A, DiPersio John F, Ding Li, Mardis Elaine R, Wilson Richard K
Abstract excerpt
Most mutations in cancer genomes are thought to be acquired after the initiating event, which may cause genomic instability and drive clonal evolution. However, for acute myeloid leukemia (AML), normal karyotypes are common, and genomic instability is unusual. To better understand clonal evolutio...
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