Article

Efficient production of functional proaerolysin from <i>E.coli</i>

2024-09-20

Abstract excerpt

Proaerolysin is a bacterial toxin produced by Aeromonas hydrophila that specifically binds to GPI-anchored proteins on the plasma membrane, creating transmembrane pores that lead to cell death within a few hours. Leveraging this unique property, proaerolysin is widely used in diagnostic tests for paroxysmal nocturnal hemoglobinuria (PNH), a disease caused by somatic mutations in the PIGA gene, which is involved...

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Literature Corpus work: 314ba3c9-8e72-5aa1-a5e9-9b5155fcae36
DOI: 10.1101/2024.09.19.613822

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