Mutations affecting the β-sheet at the extracellular opening of the intimin β-barrel domain lead to reduced protein levels and inefficient passenger secretion.

Abstract excerpt

Attaching and effacing pathogens, such as enteropathogenic and enterohaemorrhagic Escherichia coli, rely on an adhesin, intimin, for attachment to enterocytes and downstream effects leading to actin pedestal formation. Intimin belongs to the inverse autotransporter family (type 5e secretion systems), which secrete the extracellular adhesive domain or passenger via a hairpin intermediate. While many of the next...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Adhesins, Bacterial
• Share to Adhesins, Escherichia coli