Disarming <i>Burkholderia pseudomallei</i> : Structural and Functional Characterization of a Disulfide Oxidoreductase (DsbA) Required for Virulence <i>In Vivo</i>

Abstract excerpt

AIMS: The intracellular pathogen Burkholderia pseudomallei causes the disease melioidosis, a major source of morbidity and mortality in southeast Asia and northern Australia. The need to develop novel antimicrobials is compounded by the absence of a licensed vaccine and the bacterium's resistance to multiple antibiotics. In a number of clinically relevant Gram-negative pathogens, DsbA is the primary disulfide...

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