Article

Complementary constraints in germ and immune cells shape evolution of gene regulation and phenotype

2026-03-30

Abstract excerpt

New mutations arise in germ cells and must preserve fertility while altering somatic phenotype to confer a fitness advantage. To understand how whole organisms balance these constraints, we generated mice with humanized noncoding promoter sequence at Traf6 , an NF-κB pathway component with recently diverged chromatin state in mouse germ cells. The humanized allele (Traf6 h ) reinstated human-like expression in g...

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Identifiers and source

Literature Corpus work: 3141eb82-294e-5a0b-a6a8-e0ba2e6b0a80
DOI: 10.64898/2026.03.27.714809

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