Article
Allele-specific expression reveals genetic drivers of tissue regeneration in mice.
Cell stem cell - 5 Oct 2023
Mack Katya L, Talbott Heather E, Griffin Michelle F, Parker Jennifer B L, Guardino Nicholas J, Spielman Amanda F, Davitt Michael F, Mascharak Shamik, Downer Mauricio, Morgan Annah, Valencia Caleb, Akras Deena, Berger Mark J, Wan Derrick C, Fraser Hunter B, Longaker Michael T
Abstract excerpt
In adult mammals, skin wounds typically heal by scarring rather than through regeneration. In contrast, "super-healer" Murphy Roths Large (MRL) mice have the unusual ability to regenerate ear punch wounds; however, the molecular basis for this regeneration remains elusive. Here, in hybrid crosses between MRL and non-regenerating mice, we used allele-specific gene expression to identify cis-regulatory variation...
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