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Clonal Hematopoietic Mutations in Plasma Cell Disorders: Clinical Subgroups and Shared Pathogenesis.

Genomics, proteomics & bioinformatics - 30 May 2025

Wang Xuezhu, Zuo Liping, Yu Yanying, Xiong Xinyi, Xu Jian, Qiao Bing, Chen Jia, Cai Hao, Yan Qi, Han Hongxiao, Cao Xin-Xin, Deng Jun, Sun Chunyan, Li Jian

Abstract excerpt

Plasma cell disorders (PCDs) are marked by the clonal proliferation of abnormal plasma cells and bone marrow plasma cells (BMPCs), causing various clinical complications. These PCDs include subtypes with distinct clinical features. Multiple myeloma (MM) and monoclonal gammopathy of undetermined significance (MGUS) are more common and relatively well-studied. In contrast, primary light-chain amyloidosis (AL) and...

Topics

Humans
Mutation
Multiple Myeloma
Male
Middle Aged
Female
Plasma Cells
Aged
POEMS Syndrome
Adult

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Open in PubMed Open full text

Identifiers

PMID: 40152254
DOI: 10.1093/gpbjnl/qzaf027
PMCID: PMC12342758

Genes

MGA
DIS3
FAT1
KMT2D
ZFHX3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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