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Single-Cell Analysis Reveals Inflammatory–Immunosuppressive Niches in Daratumumab-Resistant Primary AL Amyloidosis

2026-03-31

Abstract excerpt

<h4>ABSTRACT</h4> Primary light-chain amyloidosis (pAL) is caused by plasma cell (PC) clones that secrete misfolded free light chains that deposit. Anti-CD38 antibody daratumumab is the first-line therapy, while ∼10–30% of patients exhibit suboptimal responses (<very good partial response, VGPR), and baseline predictors and resistance mechanisms remain under investigation. We generated a single-cell bone marrow a...

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Literature Corpus work
1c52d94b-9869-5ba9-ad03-eb88bbde7350
DOI
10.64898/2026.03.28.26349317
Open publication

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Single-Cell Analysis Reveals Inflammatory–Immunosuppressive Niches in Daratumumab-Resistant Primary AL AmyloidosisDOI 10.64898/2026.03.28.26349317
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