Article
Single-cell profiling of mitochondrial phenotyping-coupled mtDNA genotyping.
Proceedings of the National Academy of Sciences of the United States of America - 8 Sept 2026
Zhang Zhengyang, Zhang Liwei, An Peng, Zhang Xu, Xia Yi, Kang Yunlu, Chen Xiaoxia, Hua Rongrong, Zhu Yinhua, Hao Yanling, Huang Yuan, Luo Yongting, Luo Junjie, Wang Guisheng
Abstract excerpt
Simultaneously profiling mitochondrial DNA (mtDNA) heteroplasmy and phenotypic variability at the single-cell level remains a challenge due to the absence of integrated methods that map mitochondrial genotypes alongside their functional states. We introduce human single-cell mitochondrial phenotype-coupled mtDNA sequencing (scMPCDS), a platform that quantifies mtDNA mutations and heteroplasmy together with...
Read the complete abstract on PubMedTopics
- Humans
- DNA, Mitochondrial
- Single-Cell Analysis
- Mitochondria
- Phenotype
- Mutation