Article

Mechanosensitive expression of the mesenchymal subtype marker Connective Tissue Growth Factor in Glioblastoma

2022-03-29

Abstract excerpt

Mechanical forces created by the extracellular environment regulate biochemical signals that modulate the inter-related cellular phenotypes of morphology, proliferation, and migration. A rigid microenvironment induces glioblastoma (GBM) cells to develop prominent actin stress fibres, take on a spread morphology and adopt trapezoid cells shapes when cultured in 2D, which are phenotypes characteristic of a mesenchym...

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Identifiers and source

Literature Corpus work: 31008100-179c-524a-80ee-6625538219b1
DOI: 10.21203/rs.3.rs-1383852/v1

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