Brain and Breast Cancer Cells with PTEN Loss of Function Demonstrate Enhanced Durotaxis and RHOB Dependent Amoeboid Migration Using 3D Printed Scaffolds and Aligned Microfiber Tracts

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Glioblastoma multiforme (GBM) and triple-negative breast cancer (TNBC) with <italic>PTEN</italic> mutations often lead to brain dissemination with very poor patient outcomes. GBM uses axons and vessels as migratory cues to disseminate, however it is not known, if TNBC shares the same behavior. There is a need to understand brain tumor cell spreading and if GBM a...

Topics

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• Brain Neoplasms
• Cell Line, Tumor
• Cell Movement
• Glioblastoma
• MAP Kinase Signaling System
• Mice, Knockout
• Neoplasm Invasiveness
• Neoplasm Proteins

Identifiers and source

Literature Corpus work

aced4b14-5d6e-544f-b83b-33865f4e5bb3

DOI

10.21203/rs.3.rs-826338/v1