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Article

Glioma stem cells invasive phenotype at optimal stiffness is driven by MGAT5 dependent mechanosensing.

Journal of experimental & clinical cancer research : CR - 24 Apr 2021

Marhuenda Emilie, Fabre Christine, Zhang Cunjie, Martin-Fernandez Martà, Iskratsch Thomas, Saleh Ali, Bauchet Luc, Cambedouzou Julien, Hugnot Jean-Philippe, Duffau Hugues, Dennis James W, Cornu David, Bakalara Norbert

Abstract excerpt

BACKGROUND: Glioblastomas stem-like cells (GSCs) by invading the brain parenchyma, remains after resection and radiotherapy and the tumoral microenvironment become stiffer. GSC invasion is reported as stiffness sensitive and associated with altered N-glycosylation pattern. Glycocalyx thickness modulates integrins mechanosensing, but details remain elusive and glycosylation enzymes involved are unknown. Here, we...

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Identifiers

PMID: 33894774
DOI: 10.1186/s13046-021-01925-7
PMCID: PMC8067292

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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