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Article

A PUF Hub Drives Self-Renewal in Caenorhabditis elegans Germline Stem Cells.

Genetics - 1 Jan 2020

Haupt Kimberly A, Law Kimberley T, Enright Amy L, Kanzler Charlotte R, Shin Heaji, Wickens Marvin, Kimble Judith

Abstract excerpt

Stem cell regulation relies on extrinsic signaling from a niche plus intrinsic factors that respond and drive self-renewal within stem cells. A priori, loss of niche signaling and loss of the intrinsic self-renewal factors might be expected to have equivalent stem cell defects. Yet this simple prediction has not been borne out for most stem cells, including Caenorhabditis elegans germline stem cells (GSCs). The...

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Identifiers

PMID: 31740451
DOI: 10.1534/genetics.119.302772
PMCID: PMC6944405

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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