Article

Small Molecule Modulation of MHC-I Surface Expression: A Click Chemistry-Based Discovery Approach

2025-02-05

Abstract excerpt

<h4>ABSTRACT</h4> Immunotherapy has emerged as a powerful strategy for combating cancer by harnessing the patient’s immune system to recognize and eliminate malignant cells. Major histocompatibility complex class I (MHC-I) plays a pivotal role by presenting neoantigens to CD8+ T cells, triggering T cell-mediated killing. However, cancer cells often evade detection by downregulating MHC-I surface expression, hinde...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 30c74ee7-5dce-58f2-93d4-a292a418594a
DOI: 10.1101/2025.01.31.635109

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Small Molecule Modulation of MHC-I Surface Expression: A Click Chemistry-Based Discovery ApproachDOI 10.1101/2025.01.31.635109Read

<i>De Novo</i> Design of Peptide Masks Enables Rapid Generation of Conditionally-Active Miniprotein BindersSemantic proximity Read

Proteolysis-Targeting Chimeras (PROTACs) Based on Macrocyclic Tetrapeptides Selectively Degrade Class I Histone Deacetylases 1–3Semantic proximity Read

Screening of protein-protein interaction modulators via sulfo-click kinetic target-guided synthesis.Semantic proximity Read

STING-Activating Polymer-Drug Conjugates for Cancer ImmunotherapySemantic proximity Read

A Global Ligandability Map of Tryptoline Butynamide Stereoprobes Identifies Covalent Inhibitors of the Actin Maturation Protease ACTMAPSemantic proximity Read

Using Natural Product Inhibitors to Validate Hsp90 as a Molecular Target in CancerSemantic proximity Read

Design-Rules for Stapled Alpha-Helical Peptides with On-Target In Vivo Activity: Application to Mdm2/X dual antagonistsSemantic proximity Read

Heat shock protein-90 inhibitors enhance antigen expression on melanomas and increase T cell recognition of tumor cells.Semantic proximity Read

1-(Aminomethyl)-Trans-Cyclooct-4-Ene, a New TCO Derivative for Target Visualization and Target Engagement Measurement in CellsSemantic proximity Read

Expanding the DNA Damaging Potential of Artificial Metallo-Nucleases with Click ChemistrySemantic proximity Read

Streptavidin-drug conjugates streamline optimization of antibody-based conditioning for hematopoietic stem cell transplantationSemantic proximity Read

Stereoselective Covalent Targeting of BTK(C481S) and Kinases with β-Lactone ElectrophilesSemantic proximity Read