Article

1-(Aminomethyl)-Trans-Cyclooct-4-Ene, a New TCO Derivative for Target Visualization and Target Engagement Measurement in Cells

2020-11-02

Abstract excerpt

Click probes have enabled a thorough study of drug interactions in relevant disease models. Proper design of the probes, including the choice of the click moiety coupled to the drug, is crucial to ensure good performance and broad application. A new trans -cyclooctene derivative, amTCO, was synthesised using a phthalimide protecting group as a built-in photosensitiser for the cyclooctene isomerization. The 1-(ami...

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Literature Corpus work: 09851513-d4ca-5e83-85f1-a8b066e860a6
DOI: 10.26434/chemrxiv.13174286.v1

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