Article

Expanding the DNA Damaging Potential of Artificial Metallo-Nucleases with Click Chemistry

2025-04-09

Abstract excerpt

<title>Abstract</title> <p> The preparation of new metallodrugs targeting DNA is of key therapeutic interest. Recently, the copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) "click chemistry" reaction has emerged as a promising approach for designing new artificial metallo-nucleases (AMNs) with DNA-damaging properties. By functionalising a central organic azide with three alkyne donors, Tri-Click (TC) ligan...

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Literature Corpus work: 14bd54b3-93c1-5ebe-9783-6c510fe7c383
DOI: 10.21203/rs.3.rs-6347053/v1

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