Article

Streptavidin-drug conjugates streamline optimization of antibody-based conditioning for hematopoietic stem cell transplantation

2024-02-12

Abstract excerpt

<h4>ABSTRACT</h4> Hematopoietic stem cell transplantation (HSCT) conditioning using antibody-drug conjugates (ADC) is a promising alternative to conventional chemotherapy- and irradiation-based conditioning regimens. The drug payload bound to an ADC is a key contributor to its efficacy and potential toxicities; however, a comparison of HSCT conditioning ADCs produced with different toxic payloads has not been per...

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Literature Corpus work: 55cb8c3c-9470-530d-8e0d-616eec589af2
DOI: 10.1101/2024.02.12.579199

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