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Article

Screening of protein-protein interaction modulators via sulfo-click kinetic target-guided synthesis.

ACS chemical biology - 15 Jul 2011

Kulkarni Sameer S, Hu Xiangdong, Doi Kenichiro, Wang Hong-Gang, Manetsch Roman

Abstract excerpt

Kinetic target-guided synthesis (TGS) and in situ click chemistry are among unconventional discovery strategies having the potential to streamline the development of protein-protein interaction modulators (PPIMs). In kinetic TGS and in situ click chemistry, the target is directly involved in the...

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PMID: 21506574
DOI: 10.1021/cb200085q
PMCID: PMC3151735

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21506574-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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