Article

Design-Rules for Stapled Alpha-Helical Peptides with On-Target In Vivo Activity: Application to Mdm2/X dual antagonists

2023-02-26

Abstract excerpt

Stapled α-helical peptides can bind to and modulate historically intractable targets while addressing the traditional liabilities associated with peptide therapeutics. However, their pipeline advancement has been impeded by the challenges of identifying peptides with sufficient cellular uptake to engage the target protein while lacking off-target toxicities. Here, we advance the field to arrive at a workflow for i...

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Literature Corpus work: d003c852-0119-5443-bf5d-6082e4128c6c
DOI: 10.1101/2023.02.25.530030

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